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A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
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Published on: February 2, 2021

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Risk factors for acute kidney injury in vancomycin and piperacillin/tazobactam combination therapy: A retrospective

Yuma Yamashita1, Hiroshi Kawaguchi2, Tsubasa Yano1

  • 1Department of Pharmacy, Osaka City University Hospital, 1-5-7 Asahi-machi, Abeno-ku, Osaka, 545-8586, Japan.

Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy
|August 9, 2021
PubMed
Abstract

Insights

The combined use of vancomycin (VCM) and piperacillin/tazobactam (PIPC/TAZ) increases acute kidney injury (AKI) risk. Concomitant vasopressor use and same-day initiation of this antibiotic combination are identified risk factors for AKI.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Pharmacology

Background:

  • The combined administration of vancomycin (VCM) and piperacillin/tazobactam (PIPC/TAZ) is associated with an increased incidence of acute kidney injury (AKI).
  • Risk factors for AKI development following vancomycin and piperacillin/tazobactam (VPT) combination therapy remain unidentified.

Purpose of the Study:

  • To retrospectively investigate the risk factors associated with AKI development in patients treated with VPT combination therapy.

Main Methods:

  • Patients receiving VPT from January 1, 2016, to March 31, 2020, were analyzed.
  • Clinical characteristics and antimicrobial therapy were compared between AKI and non-AKI groups.
  • Multivariate logistic regression analysis was employed to evaluate AKI risk factors.

Main Results:

  • The study included 182 patients, with an AKI incidence of 35.2% (64 out of 182).
  • Same-day initiation of VPT combination therapy (OR 2.55, 95% CI 1.20-5.44) was associated with increased AKI risk.
  • Concomitant use of vasopressors (OR 3.22, 95% CI 1.31-7.89) also significantly increased AKI risk.

Conclusions:

  • Concomitant vasopressor use is a significant risk factor for AKI in patients receiving VPT.
  • Initiating VPT combination therapy on the same day is identified as a probable risk factor for AKI development.
Keywords:
Acute kidney injuryCombination therapyPiperacillin/tazobactamVancomycin

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