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Related Experiment Video

Updated: Oct 25, 2025

Quantification of Optic Nerve Cross Sectional Area on MRI: A Novel Protocol using Fiji Software
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Thin-section 3D Steady-State MRI in Optic Nerve Coloboma.

Krishnan Nagarajan1, Anusha Venkataraman2

  • 1Department of Radio-Diagnosis, Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER), Pondicherry, India.

Neuro-Ophthalmology (Aeolus Press)
|August 9, 2021
PubMed
Summary

Optic nerve colobomas, a congenital eye defect, were identified in a child with suspected morning glory disc anomaly. Thin-section 3D MRI revealed a small defect and discontinuity in the optic nerve head.

Keywords:
3D MRIOptic nerve colobomamagnetic resonance imaging

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Pediatric Neurology

Background:

  • Optic nerve colobomas are congenital malformations of the posterior eye.
  • These defects often present with characteristic, but sometimes subtle, funduscopic findings.
  • Morning glory disc anomaly is a rare type of optic nerve coloboma.

Purpose of the Study:

  • To describe the magnetic resonance imaging findings in a child with suspected morning glory disc anomaly.
  • To highlight the utility of advanced imaging in diagnosing optic nerve head defects.
  • To correlate imaging findings with clinical suspicion of congenital optic nerve anomalies.

Main Methods:

  • A two-year-old child with suspected morning glory disc anomaly was evaluated.
  • Thin-section 3D steady-state magnetic resonance imaging (MRI) of the optic nerve was performed.
  • Image analysis focused on identifying structural abnormalities of the optic nerve head.

Main Results:

  • MRI demonstrated a tiny defect in the optic nerve head.
  • Discontinuity of the optic nerve head structures was evident on imaging.
  • These findings were characteristic of optic nerve coloboma.

Conclusions:

  • Thin-section 3D MRI is effective in visualizing subtle optic nerve head defects.
  • Advanced imaging can confirm congenital optic nerve anomalies like colobomas.
  • This case underscores the role of MRI in pediatric ophthalmology for precise diagnosis.