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Related Concept Videos

Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
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Imaging Studies IV: Magnetic Resonance Imaging01:27

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Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
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Applications Of NMR In Biology01:25

Applications Of NMR In Biology

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Nuclear magnetic resonance (NMR) spectroscopy is a very valuable analytical technique for researchers. It has been used for more than 50 years as an analytical tool. F. Bloch and E. Purcell formulated NMR in 1946 and won the 1952 Nobel Prize in Physics  for their work. Biological macromolecules such as proteins, nucleic acids, lipids, and organic molecules including pharmaceutical compounds, can be studied using this versatile tool that exploits the magnetic properties of certain nuclei.
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Imaging Studies for Cardiovascular System IV: CMRI01:21

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Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
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Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
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Multinuclear MRI Research.

Yu A Pirogov1

  • 1Faculty of Physics, M. V. Lomonosov Moscow State University, Moscow, Russia.

Applied Magnetic Resonance
|August 9, 2021
PubMed
Summary

Multinuclear MRI shows promise for research and clinical applications. Techniques like hyperpolarization and fluorine-19 MRI enhance imaging of various nuclei, aiding disease diagnosis and monitoring.

Area of Science:

  • Medical Imaging
  • Biomedical Engineering
  • Nuclear Magnetic Resonance (NMR)

Background:

  • Multinuclear Magnetic Resonance Imaging (MRI) offers significant potential in both research and clinical settings.
  • The biomedical relevance of heavy nuclei in pharmaceuticals and contrast agents necessitates MRI scanners tuned to their specific Larmor frequencies.
  • Standard MRI sensitivity for heavy nuclei is often insufficient for high-quality imaging.

Purpose of the Study:

  • To explore solutions for overcoming sensitivity limitations in multinuclear MRI.
  • To demonstrate the application of multinuclear MRI in solving specific diagnostic and monitoring problems.
  • To highlight the development of infrastructure enabling multi-frequency MRI measurements.

Main Methods:

  • Utilizing hyperpolarization techniques to enhance MRI signal sensitivity for heavy nuclei.

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  • Employing alternative contrast agents, particularly fluorine-19 (19F), for targeted imaging due to its absence in biological tissues.
  • Developing specialized transmitting and receiving infrastructure for low-field (0.5 T) MRI across 10 different Larmor frequencies.

    • Main Results:

    • 19F MRI successfully diagnosed respiratory conditions, located blood substitutes, and monitored gastrointestinal transport.
    • Non-invasive measurements of sodium-23 (23Na) concentration demonstrated potential for linking deviations to pathologies like diabetes and hypertension.
    • Effective low-field MRI measurements were achieved for hydrogen, deuterium, fluorine, boron, chlorine, sodium, carbon, phosphorus, silicon, and oxygen nuclei.

    Conclusions:

    • Multinuclear MRI, enhanced by hyperpolarization or specific contrast agents like 19F, holds great promise for biomedical research and clinical diagnostics.
    • The ability to measure various nuclei non-invasively provides new avenues for diagnosing and monitoring a range of diseases.
    • The established infrastructure supports versatile, multi-frequency MRI, paving the way for broader applications of this technology.