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Recent advances in gastrointestinal cancers.

Natacha Bordry1, Christoforos Astaras1, Marie Ongaro2

  • 1Department of Oncology, University Hospital of Geneva (HUG), Genève 1205, Switzerland.

World Journal of Gastroenterology
|August 9, 2021
PubMed
Summary

This review highlights 13 practice-changing phase III gastrointestinal cancer trials from major 2020 oncology congresses. Key outcomes from these pivotal studies are summarized for clinical relevance.

Keywords:
Gastric cancerGastrointestinalGastrointestinal cancersImmunotherapyPractice changing trials

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Area of Science:

  • Oncology
  • Gastroenterology

Background:

  • Gastrointestinal cancers encompass eight distinct sites, each managed with unique treatment protocols.
  • The landscape of gastrointestinal oncology is rapidly evolving with new therapeutic strategies.

Purpose of the Study:

  • To review practice-changing phase III randomized trials in gastrointestinal cancers presented in 2020.
  • To provide concise summaries and contextualize the main outcomes of these pivotal studies.

Main Methods:

  • Focused on 13 phase III randomized controlled trials presented orally at major oncology congresses in 2020.
  • Included presentations from American Society of Clinical Oncology (ASCO), ASCO GI, European Society of Medical Oncology (ESMO), and ESMO GI.

Main Results:

  • Summarized key findings from 13 significant phase III trials across various gastrointestinal cancer types.
  • Highlighted practice-altering results that may influence clinical decision-making.

Conclusions:

  • The presented trials represent significant advancements in the standard of care for gastrointestinal malignancies.
  • Understanding these outcomes is crucial for oncologists managing patients with these diseases.