Recent advances in gastrointestinal cancers.

Area of Science:

• Oncology
• Gastroenterology

Background:

• Gastrointestinal cancers encompass eight distinct sites, each managed with unique treatment protocols.
• The landscape of gastrointestinal oncology is rapidly evolving with new therapeutic strategies.

Purpose of the Study:

• To review practice-changing phase III randomized trials in gastrointestinal cancers presented in 2020.
• To provide concise summaries and contextualize the main outcomes of these pivotal studies.

Main Methods:

• Focused on 13 phase III randomized controlled trials presented orally at major oncology congresses in 2020.
• Included presentations from American Society of Clinical Oncology (ASCO), ASCO GI, European Society of Medical Oncology (ESMO), and ESMO GI.

Main Results:

• Summarized key findings from 13 significant phase III trials across various gastrointestinal cancer types.
• Highlighted practice-altering results that may influence clinical decision-making.

Conclusions:

• The presented trials represent significant advancements in the standard of care for gastrointestinal malignancies.
• Understanding these outcomes is crucial for oncologists managing patients with these diseases.