Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Protein-protein Interfaces02:04

Protein-protein Interfaces

14.1K
Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
14.1K
Protein-Protein Interfaces02:04

Protein-Protein Interfaces

4.1K
4.1K
Protein Networks02:26

Protein Networks

4.2K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.2K
Protein Organization01:24

Protein Organization

8.1K
Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence....
8.1K
Protein Glycosylation01:25

Protein Glycosylation

8.0K
Glycosylation, the most common post-translational modification for proteins, serves diverse functions. Adding sugars to proteins makes the proteins more resistant to proteolytic digestion. Glycosylated proteins can act as markers and receptors to promote cell-cell adhesion. Additionally, they have many essential quality control functions in the cell, such as correct protein folding and facilitating transport of misfolded proteins to the cytosol, which can be degraded.
Glycosylation occurs in...
8.0K
Overview of Carbohydrate Metabolism01:19

Overview of Carbohydrate Metabolism

2.3K
Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
2.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of a novel loop-mediated isothermal amplification assay for the detection of lipolytic Pseudomonas fluorescens in raw cow milk from north China.

Journal of dairy science·2017
Same author

Electromagnetic reprogrammable coding-metasurface holograms.

Nature communications·2017
Same author

Bacterial magnetosome and its potential application.

Microbiological research·2017
Same author

Novel CD137 Gene Polymorphisms and Susceptibility to Ischemic Stroke in the Northern Chinese Han Population.

Neuromolecular medicine·2017
Same author

The Clinicopathological Factors Associated with Disease Progression in Luminal A Breast Cancer and Characteristics of Metastasis: A Retrospective Study from A Single Center in China.

Anticancer research·2017
Same author

Direct observation of topological surface-state arcs in photonic metamaterials.

Nature communications·2017
Same journal

Docking strategies for predicting protein-ligand interactions and their application to structure-based drug design.

Communications in information and systems·2024
Same journal

smFRET-assisted RNA structure prediction.

Communications in information and systems·2024
Same journal

Mathematical artificial intelligence design of mutation-proof COVID-19 monoclonal antibodies.

Communications in information and systems·2023
Same journal

SARS-CoV-2 becoming more infectious as revealed by algebraic topology and deep learning.

Communications in information and systems·2021
Same journal

Evolution of Coagulation-Fragmentation Stochastic Processes Using Accurate Chemical Master Equation Approach.

Communications in information and systems·2021
Same journal

A Bayes-inspired theory for optimally building an efficient coarse-grained folding force field.

Communications in information and systems·2021
See all related articles

Related Experiment Video

Updated: Oct 25, 2025

Concanavalin A-Based Sedimentation Assay to Measure Substrate Binding of Glucan Phosphatases
09:07

Concanavalin A-Based Sedimentation Assay to Measure Substrate Binding of Glucan Phosphatases

Published on: December 23, 2022

1.5K

Carbohydrate-Protein Interactions: Advances and Challenges.

Shuang Zhang1, Kyle Yu Chen2, Xiaoqin Zou1

  • 1Dalton Cardiovascular Research Center, Department of Physics and Astronomy, Department of Biochemistry, Institute for Data Science and Informatics, University of Missouri, Columbia, MO 65211, USA.

Communications in Information and Systems
|August 9, 2021
PubMed
Summary
This summary is machine-generated.

This review summarizes protein-carbohydrate interactions, crucial for biological processes and drug design. It covers computational methods for analyzing these complexes and discusses current challenges.

Keywords:
Carbohydrate-protein interactionsdrug discoverymolecular dockingsaccharide-protein interactionsstructure predictionsugar-protein binding

More Related Videos

Exploring Biomolecular Interaction Between the Molecular Chaperone Hsp90 and Its Client Protein Kinase Cdc37 using Field-Effect Biosensing Technology
09:39

Exploring Biomolecular Interaction Between the Molecular Chaperone Hsp90 and Its Client Protein Kinase Cdc37 using Field-Effect Biosensing Technology

Published on: March 31, 2022

3.5K
Author Spotlight: Unveiling the Structural and Dynamic Aspects of Glycan Molecular Recognition
07:40

Author Spotlight: Unveiling the Structural and Dynamic Aspects of Glycan Molecular Recognition

Published on: May 17, 2024

1.5K

Related Experiment Videos

Last Updated: Oct 25, 2025

Concanavalin A-Based Sedimentation Assay to Measure Substrate Binding of Glucan Phosphatases
09:07

Concanavalin A-Based Sedimentation Assay to Measure Substrate Binding of Glucan Phosphatases

Published on: December 23, 2022

1.5K
Exploring Biomolecular Interaction Between the Molecular Chaperone Hsp90 and Its Client Protein Kinase Cdc37 using Field-Effect Biosensing Technology
09:39

Exploring Biomolecular Interaction Between the Molecular Chaperone Hsp90 and Its Client Protein Kinase Cdc37 using Field-Effect Biosensing Technology

Published on: March 31, 2022

3.5K
Author Spotlight: Unveiling the Structural and Dynamic Aspects of Glycan Molecular Recognition
07:40

Author Spotlight: Unveiling the Structural and Dynamic Aspects of Glycan Molecular Recognition

Published on: May 17, 2024

1.5K

Area of Science:

  • Biochemistry
  • Structural Biology
  • Computational Biology

Background:

  • Carbohydrates (saccharides) are abundant biomolecules essential for life, composed of carbon, hydrogen, and oxygen.
  • Protein-carbohydrate interactions are vital in cellular functions like growth and differentiation.
  • These interactions are significant for pharmaceutical drug design.

Purpose of the Study:

  • To review characteristic features of protein-carbohydrate interactions.
  • To summarize computational methods for structure prediction, energy calculations, and kinetic studies of protein-carbohydrate complexes.
  • To discuss existing challenges in the field of protein-carbohydrate interactions.

Main Methods:

  • Literature review of characteristic features of protein-carbohydrate interactions.
  • Review of computational approaches for analyzing protein-carbohydrate complexes, including structure prediction and energy calculations.
  • Analysis of kinetic studies related to protein-carbohydrate complexes.

Main Results:

  • Protein-carbohydrate interactions are fundamental to numerous biological processes.
  • Computational methods offer powerful tools for studying these interactions.
  • The field presents ongoing challenges requiring further research.

Conclusions:

  • Understanding protein-carbohydrate interactions is key for biological insights and drug development.
  • Computational approaches are essential for detailed analysis of these complexes.
  • Addressing current challenges will advance the study of these vital molecular interactions.