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Published on: June 18, 2021
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Cerebral Autoregulation in Subarachnoid Hemorrhage
Darcy Lidington1,2, Hoyee Wan1,2, Steffen-Sebastian Bolz1,2,3
1Department of Physiology, University of Toronto, Toronto, ON, Canada.
Frontiers in Neurology
|August 9, 2021
Summary
Subarachnoid hemorrhage (SAH) disrupts cerebral autoregulation, leading to delayed cerebral ischemia and poor outcomes. New research offers hope for rectifying microvascular dysfunction and improving patient recovery.
Area of Science:
- Neuroscience
- Neurology
- Critical Care Medicine
Background:
- Subarachnoid hemorrhage (SAH) is a severe stroke subtype with high mortality and morbidity.
- Delayed cerebral ischemia (DCI) frequently complicates SAH, causing significant brain injury.
- Current treatments for SAH lack specific targeting of microvascular dysfunction, limiting clinical outcome improvements.
Purpose of the Study:
- To review the clinical significance of cerebral autoregulation in SAH.
- To provide a mechanistic overview of cerebral autoregulation and its disruption in SAH.
- To discuss current and emerging therapeutic strategies for SAH patients.
Main Methods:
- Review of clinical literature on cerebral autoregulation in SAH.
- Description of mechanisms underlying cerebral autoregulation.
- Overview of methods for measuring cerebral autoregulation in SAH patients.
Main Results:
- SAH significantly perturbs cerebral perfusion control, specifically cerebral autoregulation.
- Disrupted cerebral autoregulation is a key factor in SAH-induced brain injury.
- Emerging evidence suggests potential for therapeutic interventions targeting microvascular dysfunction.
Conclusions:
- Cerebral autoregulation plays a critical role in SAH pathophysiology.
- Understanding and monitoring cerebral autoregulation is vital for managing SAH.
- Advancements in therapeutic options offer optimism for improved patient outcomes in SAH.
