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Pruritus Features in Children with End-Stage Renal Disease Underwent Dialysis: A Cross-Sectional Study

Mehryar Mehrkash1, Seyed-Javad Golestaneh2, Yahya Madihi1

  • 1Imam Hossein Children's Hospital and Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.

International Journal of Pediatrics
|August 9, 2021
PubMed

Insights

In children with end-stage renal disease (ESRD), higher serum calcium and older age are linked to increased pruritus (itching) severity during dialysis. Managing these factors may help alleviate itching in pediatric ESRD patients.

Area of Science:

  • Pediatric Nephrology
  • Dermatology in Chronic Illness
  • Dialysis Patient Care

Background:

  • Pruritus is a common and distressing symptom in children with end-stage renal disease (ESRD).
  • Understanding the factors contributing to pruritus is crucial for improving the quality of life for these young patients undergoing dialysis.

Purpose of the Study:

  • To evaluate the characteristics of pruritus in children with ESRD undergoing dialysis.
  • To identify potential correlations between pruritus severity and clinical/laboratory parameters in pediatric ESRD patients.

Main Methods:

  • A cross-sectional study was conducted at a tertiary pediatric dialysis center.
  • Medical records of 30 children with ESRD and pruritus were reviewed for demographics, dialysis, and lab data.
  • A 4-item itch questionnaire assessed pruritus distribution, severity, frequency, and sleep disturbances.

Main Results:

  • The mean age of patients was 11.7 years; nephronophthisis was the most common CKD cause.
  • Pruritus severity correlated with age and serum parathyroid hormone (PTH) levels.
  • Higher serum calcium levels and older age were significantly associated with increased odds of severe pruritus (total score ≥ 5).

Conclusions:

  • Elevated serum calcium and advanced age are risk factors for more severe pruritus in children with ESRD.
  • These findings highlight the importance of monitoring calcium levels and considering age in managing pruritus in pediatric dialysis patients.
Abstract

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