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Related Experiment Video

Updated: Oct 25, 2025

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
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Harnessing Lactate Metabolism for Radiosensitization.

Kevin X Liu1, Emily Everdell2, Sharmistha Pal3

  • 1Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.

Frontiers in Oncology
|August 9, 2021
PubMed
Summary

Cancer cells alter lactate metabolism for growth and resistance. Targeting lactate dehydrogenase, monocarboxylate transporters, and mitochondrial pyruvate carrier may enhance radiation therapy effectiveness in cancer treatment.

Keywords:
Warburg phenomenonlactate metabolismradiation therapyradiosensitizationsynergistic effects

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Area of Science:

  • Oncology
  • Cancer Metabolism
  • Radiotherapy

Background:

  • Cancer cells exhibit metabolic reprogramming to support proliferation, invasion, and metastasis.
  • Lactate pathway alterations in cancer are linked to patient outcomes and resistance to therapies.
  • Overcoming radio-resistance is crucial for improving cancer treatment efficacy, as radiotherapy is a common modality.

Purpose of the Study:

  • To review lactate metabolism in cancer.
  • To discuss key regulators of lactate metabolism: lactate dehydrogenase, monocarboxylate transporters, and mitochondrial pyruvate carrier.
  • To present evidence that inhibiting these pathways can sensitize cancer cells to radiation.

Main Methods:

  • Literature review of lactate metabolism in cancer.
  • Analysis of the roles of lactate dehydrogenase, monocarboxylate transporters, and mitochondrial pyruvate carrier.
  • Examination of preclinical data on the radiosensitizing effects of inhibiting these targets.

Main Results:

  • Lactate metabolism is significantly altered in cancer cells.
  • Lactate dehydrogenase, monocarboxylate transporters, and mitochondrial pyruvate carrier are critical regulators.
  • Inhibition of these three pathways demonstrates potential for radiosensitization.

Conclusions:

  • Targeting lactate metabolism offers a promising strategy to overcome cancer radio-resistance.
  • Further research is needed to explore clinical applications of lactate pathway inhibitors in combination with radiation.
  • Understanding lactate metabolism regulators is key for developing novel cancer therapeutics.