Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Stem Cell Niche01:26

Stem Cell Niche

5.6K
The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
5.6K
Overview of Hematopoiesis01:20

Overview of Hematopoiesis

5.7K
Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
5.7K
Hematopoiesis01:21

Hematopoiesis

7.2K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
7.2K
Role of Hematopoietic Growth Factors01:28

Role of Hematopoietic Growth Factors

2.1K
Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
2.1K
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

3.5K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.5K
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

3.5K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mitochondrial degradation of metallothionein enables local zinc mobilization during zinc limitation.

bioRxiv : the preprint server for biology·2026
Same author

Direct RNA Sequencing reveals epitranscriptomic regulation of brain cells and Alzheimer's Disease pathology.

bioRxiv : the preprint server for biology·2026
Same author

Oxidative stress causes a reversible decrease of deubiquitylases activity in old vertebrate brains.

Nature communications·2026
Same author

Extracellular matrix-associated molecules of senescent cells induce a senescence phenotype in proliferative cells via TGF-β signaling pathway.

Biomaterials·2026
Same author

Mesenchymal stromal cells modulate survival and regeneration of human hematopoietic stem cells via PGE2/cAMP signaling.

Cell death & disease·2026
Same author

The microcephaly-associated protein YIPF5 differentially regulates ER export.

iScience·2026

Related Experiment Video

Updated: Oct 25, 2025

Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging
10:03

Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging

Published on: August 1, 2017

11.9K

The Hematopoietic Bone Marrow Niche Ecosystem.

Julia Fröbel1, Theresa Landspersky2, Gülce Percin1

  • 1Immunology of Aging, Leibniz Institute on Aging - Fritz Lipmann Institute, Jena, Germany.

Frontiers in Cell and Developmental Biology
|August 9, 2021
PubMed
Summary
This summary is machine-generated.

The bone marrow niche protects hematopoietic stem cells (HSCs) during stress. Chronic stress and aging damage this niche, impairing HSC function and increasing disease risk.

Keywords:
agingbone marrowhematopoiesisleukemiamicroenvironmentnichetransplantationxenograft

More Related Videos

Combining Intravital Fluorescent Microscopy IVFM with Genetic Models to Study Engraftment Dynamics of Hematopoietic Cells to Bone Marrow Niches
11:06

Combining Intravital Fluorescent Microscopy IVFM with Genetic Models to Study Engraftment Dynamics of Hematopoietic Cells to Bone Marrow Niches

Published on: March 21, 2017

8.1K
Flow Cytometry Analysis of Murine Bone Marrow Hematopoietic Stem and Progenitor Cells and Stromal Niche Cells
08:34

Flow Cytometry Analysis of Murine Bone Marrow Hematopoietic Stem and Progenitor Cells and Stromal Niche Cells

Published on: September 28, 2022

4.9K

Related Experiment Videos

Last Updated: Oct 25, 2025

Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging
10:03

Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging

Published on: August 1, 2017

11.9K
Combining Intravital Fluorescent Microscopy IVFM with Genetic Models to Study Engraftment Dynamics of Hematopoietic Cells to Bone Marrow Niches
11:06

Combining Intravital Fluorescent Microscopy IVFM with Genetic Models to Study Engraftment Dynamics of Hematopoietic Cells to Bone Marrow Niches

Published on: March 21, 2017

8.1K
Flow Cytometry Analysis of Murine Bone Marrow Hematopoietic Stem and Progenitor Cells and Stromal Niche Cells
08:34

Flow Cytometry Analysis of Murine Bone Marrow Hematopoietic Stem and Progenitor Cells and Stromal Niche Cells

Published on: September 28, 2022

4.9K

Area of Science:

  • Hematology
  • Stem Cell Biology
  • Microenvironment Biology

Background:

  • The bone marrow (BM) microenvironment, or niche, is crucial for lifelong hematopoiesis.
  • Physiologic conditions maintain hematopoietic stem cell (HSC) protection within the niche.
  • Stress can disrupt hematopoiesis indirectly by altering the BM niche's cellular composition and signaling.

Purpose of the Study:

  • To describe how BM niche alterations modulate HSC activation.
  • To elucidate the impact of chronic stimulation and aging on the BM niche and HSCs.
  • To review xenotransplantation as a model for studying niche homeostasis.

Main Methods:

  • Review of current knowledge on BM niche composition and structure.
  • Analysis of cellular maintenance processes (autophagy, ER stress response, DNA repair) in HSCs.
  • Examination of xenotransplantation models to understand niche factor dependence.

Main Results:

  • Chronic stress leads to significant BM remodeling and HSC loss due to impaired cellular maintenance.
  • Aging of the BM niche results from intermittent stress responses, degenerating the supportive microenvironment.
  • Both chronic stress and aging compromise HSC functionality and elevate disease susceptibility, including malignancy.

Conclusions:

  • Understanding BM niche homeostasis is key to comprehending functional degeneration.
  • Deviations from steady-state niche function can be assessed using insights from xenotransplantation.
  • Protecting and restoring the BM niche ecosystem is vital for sustaining healthy hematopoiesis in various settings.