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p73 as a Tissue Architect.

Laura Maeso-Alonso1, Lorena López-Ferreras1, Margarita M Marques2

  • 1Departamento de Biología Molecular, Instituto de Biomedicina (IBIOMED), University of León, León, Spain.

Frontiers in Cell and Developmental Biology
|August 9, 2021
PubMed
Summary
This summary is machine-generated.

The TP73 gene, encoding p73, acts as a crucial tissue architect, regulating cell adhesion and polarity. Its role extends beyond growth suppression to maintaining tissue homeostasis and organization in various microenvironments.

Keywords:
actin cytoskeletoncell adhesioncell polaritycentral nervous system developmentneurogenic nichep53-familyp73tissue architecture

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Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

Background:

  • The TP73 gene is part of the p53 family, regulating cell proliferation and death.
  • p73's function is vital for tissue homeostasis beyond its growth-suppressive roles.
  • p73 is essential for organizing complex microenvironments like neurogenic niches and reproductive organs.

Purpose of the Study:

  • To review the role of p73 as a tissue architect.
  • To explore p73's regulation of cell adhesion, cytoskeleton dynamics, and Planar Cell Polarity.
  • To provide an overview of TAp73 as a central modulator of these functions.

Main Methods:

  • Literature review of p73 function in tissue architecture.
  • Analysis of p73's role in neurogenic niche organization.
  • Overview of TAp73's function as a hub modulator.

Main Results:

  • p73 functions as a tissue architect, essential for tissue organization and homeostasis.
  • p73 regulates cell adhesion, cytoskeleton dynamics, and Planar Cell Polarity.
  • TAp73 acts as a hub modulator influencing multiple cellular functions.

Conclusions:

  • p73 is a critical tissue architect, maintaining the integrity of cellular and extracellular compartments.
  • Alterations in p73 function can lead to various developmental phenotypes.
  • Understanding p73's role is key to comprehending tissue physiology and disease.