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Updated: Oct 25, 2025

Author Spotlight: Peptidome Extraction from Small Extracellular Vesicles Isolated from Bone Marrow-Derived Macrophages
Published on: June 30, 2023
The Biogenesis, Biological Functions, and Applications of Macrophage-Derived Exosomes
Xiaoxiao Shan1,2,3, Caiyun Zhang1,2,3, Chutian Mai4
1School of Pharmacy, Anhui Academy of Chinese Medicine, , Anhui University of Traditional Chinese MedicineHefei, China.
Abstract:
Macrophage-derived exosomes have been implicated on the modulation of inflammatory processes. Recent studies have shown that macrophage-derived exosomes contribute to the progression of many diseases such as cancer, atherosclerosis, diabetes and heart failure. This review describes the biogenesis of macrophage-derived exosomes and their biological functions in different diseases. In addition, the challenges facing the use of macrophage-derived exosomes as delivery tools for drugs, genes, and proteins in clinical applications are described. The application of macrophage-derived exosomes in the diagnosis and treatment of diseases is also discussed.
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