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Corrected QT Interval Is Associated With Stroke but Not Coronary Heart Disease: Insights From a General Chinese

Xiaofan Guo1, Zhao Li1, Ying Zhou1

  • 1Department of Cardiology, The First Hospital of China Medical University, Shenyang, China.

Frontiers in Cardiovascular Medicine
|August 9, 2021
PubMed

Insights

A prolonged heart rate-corrected QT (QTc) interval is linked to higher risks of stroke and cardiovascular diseases (CVD) in Chinese adults. This association highlights QTc interval as a potential predictor for cardiovascular events in this population.

Area of Science:

  • Cardiology
  • Public Health
  • Epidemiology

Background:

  • Prolonged QTc interval is linked to cardiovascular diseases (CVD) in Western populations.
  • The association between QTc interval and CVD risk in Asian populations remains unclear.
  • This study investigated the QTc interval and incident CVD link in a Chinese population.

Purpose of the Study:

  • To determine the association between QTc interval and incident CVD in a general Chinese population.
  • To assess the relationship between QTc interval and specific CVD events like stroke and coronary heart disease (CHD).
  • To evaluate QTc interval as a potential predictor of cardiovascular events in Chinese adults.

Main Methods:

  • Analysis of 8,867 participants aged ≥35 years, free of CVD at baseline, from the Northeast China Rural Cardiovascular Health Study.
  • Resting 12-lead electrocardiogram to compute QTc interval using the Framingham formula.
  • Cox proportional hazards models to assess associations between QTc interval and incident stroke, CHD, and combined CVD events.

Main Results:

  • Over 4.66 years, 439 CVD events occurred (298 stroke, 152 CHD).
  • Prolonged QTc interval was associated with increased risk of stroke (HR: 1.82) and combined CVD (HR: 1.52).
  • Each 10 ms QTc increase correlated with higher stroke (HR: 1.12) and combined CVD (HR: 1.10) risk; no significant association with CHD.

Conclusions:

  • Baseline QTc interval is associated with incident stroke and CVD in Chinese adults without prior CVD.
  • QTc interval may serve as a valuable predictor for cardiovascular events in the Chinese population.
  • Further research is warranted to explore the clinical implications of QTc interval in CVD prevention among Asian populations.

Keywords:
QTc intervalcardiovascular diseasecoronary heart diseaseelectrocardiogramstroke

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