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Cardiac Shock Wave Therapy Ameliorates Myocardial Ischemia in Patients With Chronic Refractory Angina Pectoris: A

Liu Weijing1, Fan Ximin1, Shen Jianying1

  • 1Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.

Frontiers in Cardiovascular Medicine
|August 9, 2021
PubMed

Insights

Cardiac shock wave therapy (CSWT) offers a safe and effective non-invasive treatment for chronic refractory angina pectoris (CRAP). CSWT significantly improves patient symptoms and myocardial perfusion without adverse effects.

Area of Science:

  • Cardiology
  • Non-invasive therapies

Background:

  • Chronic refractory angina pectoris (CRAP) presents a significant clinical challenge.
  • Cardiac shock wave therapy (CSWT) is an emerging non-invasive treatment option.

Purpose of the Study:

  • To evaluate the safety and efficacy of CSWT in patients with CRAP.
  • To assess improvements in angina severity, quality of life, and myocardial perfusion.

Main Methods:

  • Eighty-seven CRAP patients were randomized into CSWT (n=46) and control (n=41) groups.
  • Evaluated Canadian Cardiovascular Society (CCS) grade, Seattle Angina Questionnaire (SAQ) score, 6-min walk test (6MWT), and D-SPECT myocardial perfusion.
  • Monitored adverse events throughout the study.

Main Results:

  • CSWT was well-tolerated, with no significant adverse events reported.
  • Significant improvements observed in CCS grade, SAQ score, and 6MWT in the CSWT group (p < 0.05).
  • Reduced ischemic areas on D-SPECT imaging post-CSWT, with no changes in the control group.

Conclusions:

  • CSWT demonstrates potential to improve myocardial perfusion and alleviate clinical symptoms in CRAP patients.
  • The therapy is safe and non-invasive, offering a viable treatment option for CRAP.
  • Further research supports CSWT as a promising therapeutic strategy for refractory angina.

Keywords:
anginaangiogenesiscardiac shock wave therapyrandomized trialrefractory angina pectoris

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