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Updated: Oct 13, 2026

Nasolacrimal Lavage as a Treatment for Ocular Surface Toxic Soup Syndrome
Published on: April 25, 2025
Successful management of chronic Blepharo-rosacea associated demodex by lid scrub with terpinen-4-ol
Han Y Yin1,2,3, Sean Tighe3,4,5, Scheffer Cg Tseng5,6
1SUNY Upstate Medical University, Department of Ophthalmology and Visual Sciences, Syracuse, NY, USA.
Purpose:
To report a successful treatment of chronic rosacea associated ocular demodicosis with lid scrub containing terpinen-4-ol (T4O).
Observations:
A 72-year old woman presented with recurrent and refractory ocular erythema, irritation, dryness, and photophobia despite conventional medical treatment (artificial tears, hypochlorous acid lid hygiene, doxycycline, and erythromycin) for 5 years. Examination revealed facial erythema, telangiectasias on cheeks, nose and lids, and cylindrical dandruff (CD) on bilateral upper and lower lashes. Epilation sampling confirmed demodicosis. After treatment with lid wipe containing T4O (Cliradex, Biotissue, Miami, FL) over face and lids, ocular discomfort, CD, facial and eyelid erythema, telangiectatic vessels were significantly reduced. Complete eradication of demodex mites and resolution of symptoms and signs lasted 8 months of follow-up.
Conclusions:
This case suggests that T4O is effective in treating chronic rosacea associated ocular demodex blepharitis.

