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Synthesis of α-Amino Acid N-Carboxyanhydrides
Guillaume Laconde1, Muriel Amblard1, Jean Martinez1
1Institut des Biomolécules Max Mousseron, IBMM UMR 5247 CNRS, Université Montpellier, ENSCM, Faculté de Pharmacie, 15 Av. C. Flahault, 34093 Montpellier, France.
Abstract:
A simple phosgene- and halogen-free method for synthesizing α-amino acid N-carboxyanhydrides (NCAs) is described. The reaction between Boc-protected α-amino acids and T3P reagent gave the corresponding NCA derivatives in good yield and purity with no detectable epimerization. The process is safe, is easy-to-operate, and does not require any specific installation. It generates nontoxic, easy to remove byproducts. It can apply to the preparation of NCAs for the on-demand on-site production of either little or large quantities.
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