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A Case Study of Lance-Adams Syndrome.

Adam Shugan1

  • 1Department of Neurology and Neurodiagnostics, Malcom Randall VA Medical Center, Gainesville, Florida.

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Summary

Lance-Adams syndrome (LAS) is a rare neurological disorder characterized by jerky movements (myoclonus) that appear days or weeks after a hypoxic event. This case highlights LAS development in a 64-year-old male post-cardiac arrest.

Keywords:
Action myoclonusLance-Adams syndrome (LAS)hypoxic eventmyoclonic status epilepticus

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Area of Science:

  • Neurology
  • Neuroscience
  • Critical Care Medicine

Background:

  • Lance-Adams syndrome (LAS) is a rare form of posthypoxic myoclonus, with fewer than 150 reported cases globally.
  • LAS is distinct from acute posthypoxic myoclonus, typically presenting days to weeks after an anoxic event, unlike the immediate onset in acute forms.
  • Patients with LAS generally retain neurological function, contrasting with the deep coma and poor prognosis associated with acute posthypoxic myoclonus.

Observation:

  • This report details a case of a 64-year-old male who developed Lance-Adams syndrome following cardiac arrest.
  • The patient's clinical course was monitored from intensive care unit (ICU) admission through outpatient follow-up.
  • Multiple electroencephalograms (EEGs) were utilized to track the progression of his condition.

Findings:

  • The case illustrates the characteristic delayed onset of myoclonus in Lance-Adams syndrome after a hypoxic insult.
  • Serial EEGs likely showed characteristic changes indicative of Lance-Adams syndrome, aiding in diagnosis and monitoring.
  • The patient's neurological function was preserved, consistent with the typical presentation of LAS.

Implications:

  • This case contributes to the limited body of literature on Lance-Adams syndrome, aiding in understanding its clinical spectrum.
  • Recognizing the distinct features of LAS is crucial for accurate diagnosis and appropriate patient management.
  • Further research into the pathophysiology and treatment of LAS may improve outcomes for affected individuals.