Related Experiment Video
Updated: Oct 25, 2025
04:39
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
2.0K
Is thyroid autoimmunity a predisposing factor for fibromyalgia? A systematic review and meta-analysis
Seoeun Park1, Jeong-Seung Kwon2, Yong-Beom Park3
1Department of Oral Medicine and Oral Diagnosis, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Korea.
Clinical and Experimental Rheumatology
|August 9, 2021
Summary
Thyroid autoimmunity is more common in fibromyalgia patients. Postmenopausal status was also more frequent in fibromyalgia patients with thyroid autoantibodies, suggesting a link between these conditions.
Area of Science:
- Rheumatology
- Endocrinology
- Immunology
Background:
- Autoimmune thyroid disease and thyroid autoantibodies are linked to fibromyalgia and chronic pain.
- Understanding this association is crucial for patient care.
Purpose of the Study:
- To investigate the relationship between fibromyalgia and thyroid autoimmunity.
- To explore clinical symptoms and depression in relation to thyroid autoantibodies in fibromyalgia patients.
Main Methods:
- A meta-analysis of 5 case-control studies (from 10 original studies) published between 1980 and 2020.
- Searched PubMed and Embase databases for relevant literature.
- Analyzed thyroid autoantibody positivity, clinical symptoms, and depression in fibromyalgia patients versus controls.
Main Results:
- Thyroid autoantibody positivity was significantly higher in fibromyalgia patients compared to healthy controls.
- Postmenopausal status was more frequent in fibromyalgia patients with thyroid autoantibodies.
- Disease severity and depression prevalence did not differ significantly based on thyroid autoantibody status.
Conclusions:
- Thyroid autoimmunity is a relevant consideration in fibromyalgia patients.
- A higher percentage of menopausal women were observed in the fibromyalgia group with thyroid autoantibodies.
More Related Videos
Related Concept Videos
01:29Autoimmune Disorders
947
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
947
01:20Myasthenia Gravis: Overview and Treatment
2.2K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
2.2K
01:20Synthesis and Regulation of Thyroid Hormones
5.9K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
5.9K
01:15Myasthenia Gravis: Diagnostic Tests
1.5K
Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
1.5K
02:26NF-κB-dependent Signaling Pathway
8.0K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
NF-κB-dependent Signaling Mechanism
The...
8.0K
01:11Genome-wide Association Studies-GWAS
14.8K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
14.8K