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Microfluidics in Assessing Platelet Function
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The role of viscoelastic testing in assessing peri-interventional platelet function and coagulation
Udaya S Tantry1, Jan Hartmann2, Matthew D Neal3
1Sinai Center for Thrombosis Research and Drug Development, Sinai Hospital of Baltimore, Baltimore, MD, USA.
Platelets
|August 9, 2021
Summary
Viscoelastic Hemostatic Assays (VHAs) rapidly assess platelet function and coagulation during procedures. These tests aid in reducing transfusions and bleeding, and predicting adverse events across various medical settings.
Area of Science:
- Hemostasis and Thrombosis
- Point-of-Care Testing
- Transfusion Medicine
Background:
- Standard coagulation tests offer limited insights into peri-interventional hemostasis.
- Platelet function and coagulation dynamics are critical in diverse clinical scenarios.
- Viscoelastic Hemostatic Assays (VHAs) provide rapid, comprehensive hemostatic assessment.
Purpose of the Study:
- To review the role of VHAs in assessing peri-interventional platelet function and coagulation.
- To explore the application of VHAs across various clinical settings.
- To evaluate the benefits of VHAs compared to standard laboratory measures.
Main Methods:
- Comprehensive literature search of MEDLINE (PubMed) and EMBASE databases.
- Inclusion of 130 relevant articles covering basic science and clinical applications of VHAs.
- Synthesis of evidence to describe the role and utility of VHAs.
Main Results:
- VHAs offer faster, comprehensive assessment of platelet and coagulation contributions to clotting.
- VHAs demonstrate benefits in reducing allogeneic transfusion needs and bleeding.
- VHAs show potential in predicting ischemic events and improving outcomes in peri-interventional settings.
Conclusions:
- VHAs play a significant role in managing hemostasis in various peri-interventional settings.
- VHAs complement standard coagulation tests, offering faster and more comprehensive data.
- Further research is warranted to solidify the utility of VHAs in specific peri-interventional cases.
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