Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Necrosis01:16

Necrosis

5.1K
Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
5.1K
Overview of Cell Death01:30

Overview of Cell Death

8.1K
Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the...
8.1K
Ferromagnetism01:31

Ferromagnetism

2.6K
Materials like iron, nickel, and cobalt consist of magnetic domains, within which the magnetic dipoles are arranged parallel to each other. The magnetic dipoles are rigidly aligned in the same direction within a domain by quantum mechanical coupling among the atoms. This coupling is so strong that even thermal agitation at room temperature cannot break it. The result is that each domain has a net dipole moment. However, some materials have weaker coupling, and are ferromagnetic at lower...
2.6K
Ferrocement01:30

Ferrocement

430
Ferro-cement is a distinctive construction material that represents an innovative variant of reinforced concrete, characterized by its unique composition and the method by which it is formed. Unlike standard reinforced concrete, which relies on larger steel bars for reinforcement, ferro-cement utilizes densely packed layers of mesh or fine rods, fully encased in cement mortar. This composition allows for the creation of structures that are significantly thinner and more flexible than their...
430
The Early Endosome: Endocytosis of Transferrin01:28

The Early Endosome: Endocytosis of Transferrin

3.9K
Essential proteins such as insulin or low-density lipoprotein (LDL) and micronutrients such as iron enter a eukaryotic cell through receptor-mediated endocytosis. Subsequently, the early endosomes fuse with the vesicles containing such receptor-ligand complexes and play a vital role in sorting the incoming ligands and receptors. While the ligands are either degraded inside the vesicle or released into the cytosol, their receptors are returned to the plasma membrane for further rounds of...
3.9K
Corrosion02:49

Corrosion

26.4K
The degradation of metals due to natural electrochemical processes is known as corrosion. Rust formation on iron, tarnishing of silver, and the blue-green patina that develops on copper are examples of corrosion. Corrosion involves the oxidation of metals. Sometimes it is protective, such as the oxidation of copper or aluminum, wherein a protective layer of metal oxide or its derivatives forms on the surface, protecting the underlying metal from further oxidation. In other cases, corrosion is...
26.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Peanut Shaped Microrobots for Anticancer Therapy.

... International Conference on Manipulation Automation and Robotics at Small Scales (MARSS). International Conference on Manipulation Automation and Robotics at Small Scales·2026
Same author

Differential KEAP1/NRF2 mediated signaling widens the therapeutic window of redox-targeting drugs in SCLC therapy.

Nature communications·2026
Same author

Author Correction: 7-Dehydrocholesterol is an endogenous suppressor of ferroptosis.

Nature·2026
Same author

Riboflavin metabolism shapes FSP1-driven ferroptosis resistance.

Nature cell biology·2026
Same author

PRDX6 contributes to selenocysteine metabolism and ferroptosis resistance.

Molecular cell·2025
Same author

Circulating tumor cell plasticity determines breast cancer therapy resistance via neuregulin 1-HER3 signaling.

Nature cancer·2025

Related Experiment Video

Updated: Oct 25, 2025

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
04:01

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

Published on: March 15, 2024

1.3K

Ferroptosis: Concepts and Definitions.

Andrés F Flórez1, Hamed Alborzinia2

  • 1Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA. andrewflorez@gmail.com.

Advances in Experimental Medicine and Biology
|August 9, 2021
PubMed
Summary

Ferroptosis, a novel cell death form, is increasingly linked to disease pathology. This work introduces ferroptosis mechanisms and its connection to human diseases like neurodegeneration and infectious diseases.

Keywords:
ApoptosisFerroptosisHallmarks of ferroptosisPyroptosisTfR1Transsulfuration

More Related Videos

Ferritinophagy: Assessing the Selective Degradation of Iron by Autophagy in Human Fibroblasts
09:21

Ferritinophagy: Assessing the Selective Degradation of Iron by Autophagy in Human Fibroblasts

Published on: February 23, 2024

1.1K
Labeling Stem Cells with Ferumoxytol, an FDA-Approved Iron Oxide Nanoparticle
05:05

Labeling Stem Cells with Ferumoxytol, an FDA-Approved Iron Oxide Nanoparticle

Published on: November 4, 2011

21.1K

Related Experiment Videos

Last Updated: Oct 25, 2025

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
04:01

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

Published on: March 15, 2024

1.3K
Ferritinophagy: Assessing the Selective Degradation of Iron by Autophagy in Human Fibroblasts
09:21

Ferritinophagy: Assessing the Selective Degradation of Iron by Autophagy in Human Fibroblasts

Published on: February 23, 2024

1.1K
Labeling Stem Cells with Ferumoxytol, an FDA-Approved Iron Oxide Nanoparticle
05:05

Labeling Stem Cells with Ferumoxytol, an FDA-Approved Iron Oxide Nanoparticle

Published on: November 4, 2011

21.1K

Area of Science:

  • Cell Biology
  • Pathology
  • Biomedical Science

Background:

  • Ferroptosis is an iron-dependent form of regulated cell death.
  • Emerging evidence links ferroptosis to the pathological mechanisms of various human diseases.
  • Understanding ferroptosis is crucial for developing new therapeutic strategies.

Purpose of the Study:

  • To introduce the fundamental concepts and pathways of ferroptosis.
  • To explore the recent advancements in ferroptosis research, particularly its role in infectious diseases and neurodegeneration.
  • To broaden the understanding of ferroptosis regulation and its connection to human diseases.

Main Methods:

  • Literature review of ferroptosis research.
  • Synthesis of current knowledge on ferroptosis pathways.
  • Discussion of disease-specific ferroptosis mechanisms.

Main Results:

  • Ferroptosis is a distinct cell death pathway with unique biochemical features.
  • Ferroptosis plays a significant role in the pathogenesis of neurodegenerative disorders and infectious diseases.
  • The regulation of ferroptosis is complex and involves multiple molecular players.

Conclusions:

  • Ferroptosis is a critical area of research with significant implications for human health.
  • Further investigation into ferroptosis mechanisms will likely uncover novel therapeutic targets.
  • This work aims to stimulate new research in the emerging field of ferroptosis and disease.