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Second-Generation Antimitotics in Cancer Clinical Trials.

Pedro Novais1,2,3, Patrícia M A Silva1, Isabel Amorim4

  • 1CESPU, Institute of Research and Advanced Training in Health Sciences and Technologies (IINFACTS), Rua Central de Gandra, 1317, 4585-116 Gandra, Portugal.

Pharmaceutics
|August 10, 2021
PubMed
Summary

Second-generation antimitotics targeting the spindle assembly checkpoint (SAC) show promise for cancer therapy. Combination therapies may enhance the efficacy of these microtubule-independent agents, overcoming resistance and toxicity limitations.

Keywords:
antimitoticscancerclinical trialsmitotic slippagespindle assembly checkpoint

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