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Related Experiment Video

Updated: Oct 25, 2025

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

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Published on: August 15, 2016

Cyclodextrin Multicomponent Complexes: Pharmaceutical Applications.

Virginia Aiassa¹, Claudia Garnero¹, Marcela R Longhi¹

¹Unidad de Investigación y Desarrollo en Tecnología Farmacéutica, UNITEFA-CONICET, Departamento de Ciencias Farmacéuticas, Facultad Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba 5000, Argentina.

|August 10, 2021

Summary

This summary is machine-generated.

This review explores using auxiliary substances with cyclodextrins (CDs) to improve drug delivery. Multicomponent cyclodextrin complexes enhance drug solubility, stability, and bioavailability for better therapeutic outcomes.

Keywords:

auxiliary agents complexation efficiency amino acids organic acids organic bases water-soluble polymers

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Area of Science:

Pharmaceutical Sciences
Supramolecular Chemistry

Background:

Cyclodextrins (CDs) are water-soluble cyclic oligosaccharides used as pharmaceutical carriers.
CDs form complexes with drugs, modulating their properties.
Auxiliary substances can enhance the formation and efficacy of drug-CD complexes.

Purpose of the Study:

To review the use of auxiliary excipients in forming multicomponent cyclodextrin complexes.
To highlight the impact of these complexes on drug properties and therapeutic applications.

Main Methods:

Literature review of multicomponent complexation strategies.
Analysis of auxiliary excipients including amino acids, organic acids/bases, and polymers.
Evaluation of enhanced drug properties: solubility, dissolution, permeation, stability, and bioavailability.

Main Results:

Multicomponent complexation significantly improves drug solubility and dissolution rates.
Enhanced drug permeation and stability were observed with auxiliary excipients.
Improved bioavailability and therapeutic effects of various drugs were demonstrated.

Conclusions:

Auxiliary substances are effective in enhancing multicomponent cyclodextrin complexation.
These complexes offer a promising strategy for improving drug delivery and therapeutic efficacy.