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Generation, Amplification, and Titration of Recombinant Respiratory Syncytial Viruses
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Functional Features of the Respiratory Syncytial Virus G Protein

Larry J Anderson1, Samadhan J Jadhao1, Clinton R Paden2

  • 1Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.

Viruses
|August 10, 2021
PubMed

Insights

Respiratory syncytial virus (RSV) poses a significant global health threat, particularly to young children and the elderly. The G protein of RSV shows promise as a target for new vaccines and antiviral drugs.

Area of Science:

  • Virology
  • Immunology
  • Infectious Diseases

Background:

  • Respiratory syncytial virus (RSV) causes severe lower respiratory tract infections globally, impacting children under five and vulnerable adults.
  • Despite high disease burden, effective vaccines and antivirals remain elusive, with only immune prophylaxis available for select infants.

Purpose of the Study:

  • To review the features of the RSV G protein relevant to infection biology, host immune response, and disease.
  • To evaluate the potential of the G protein as a target for vaccine and antiviral drug development.

Main Methods:

  • Literature review focusing on the biological functions and immunological relevance of the RSV G protein.
  • Analysis of the G protein's role in viral entry, host immune modulation, and disease pathogenesis.

Main Results:

  • The G protein mediates cell surface binding and facilitates viral cellular infection.
  • It modulates host immune responses, influencing both immunity and disease severity.
  • The CX3C amino acid motif within the G protein is implicated in many of these functions.

Conclusions:

  • The RSV G protein's multifaceted roles in infection and immunity highlight its potential as a target for therapeutic intervention.
  • Antibodies targeting the G protein can block its effects, supporting its utility in vaccine and antiviral design.

Keywords:
G proteinpathogenesisrespiratory syncytial virustreatmentvaccines

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