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Related Experiment Videos

Radioisotope scanning using a gamma camera.

H Berry, J J Barrett, A Ford-Hutchinson

    Annals of the Rheumatic Diseases
    |February 1, 1978
    PubMed
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    A novel radioactive index for rheumatoid arthritis joint assessment showed poor correlation with standard clinical measurements in a double-blind study. This suggests it may not be a reliable indicator of disease change in clinical trials.

    Area of Science:

    • Rheumatology
    • Medical Imaging
    • Biomarkers

    Background:

    • Rheumatoid arthritis (RA) is a chronic autoimmune disease causing joint inflammation and damage.
    • Accurate and reliable measurement of disease activity is crucial for effective RA management.
    • Conventional clinical trial measurements for RA may have limitations in detecting subtle changes.

    Purpose of the Study:

    • To evaluate the utility of a novel radioactive index as a measure of disease activity in rheumatoid arthritis.
    • To assess the correlation between this radioactive index and conventional clinical measurements in a placebo-controlled study.

    Main Methods:

    • A double-blind, placebo-controlled, crossover study involving 16 outpatients with rheumatoid arthritis.
    • Utilized a gamma camera to measure a radioactive index, quantifying radioactive counts over affected joints and adjacent normal bone.

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  • Compared radioactive index data with conventional clinical trial measurements of disease change.

    • Main Results:

    • The radioactive index demonstrated a poor correlation with other conventional measurements used in the clinical trial.
    • This indicates a potential discrepancy between the radioactive index and established clinical assessments of rheumatoid arthritis progression or response.

    Conclusions:

    • The investigated radioactive index may not be a suitable or reliable biomarker for assessing disease activity or treatment response in rheumatoid arthritis clinical trials.
    • Further research is needed to validate or refine novel imaging biomarkers for RA assessment.