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Response to Vaccination against Mumps in Medical Students: Two Doses Are Needed
Andrea Trevisan1, Angelo Moretto1, Chiara Bertoncello1
1Department of Cardiac Thoracic Vascular Sciences and Public Health, University of Padova, via Giustiniani 2, 35128 Padova, Italy.
Abstract:
Mumps is a vaccine-preventable infectious disease diffuse worldwide. The implementation of mumps vaccination reduced largely the spread of infection. On 11,327 Medical School students the prevalence of mumps positive antibodies was evaluated according to dose/doses of vaccine, year of birth and sex. Compliance to mumps vaccine was low in students born before 1990 but increased consistently after this year, above all compliance to two doses, due to the implementation of the vaccine offer. Positivity of mumps antibodies is significantly (p < 0.0001) lower in students vaccinated once (71.2%) compared to those vaccinated twice (85.4%). In addition, students born after 1995, largely vaccinated twice, showed a seropositivity near to 90%. Further, females had a significantly (p < 0.0001) higher proportion of positive antibodies after vaccination than males, both one (74.6% vs. 64.7%) and two doses (86.8% vs. 82.9%). Finally, seropositivity after two vaccine doses remains high (86.1%) even 15 years after the second dose. In conclusion, the research highlighted that vaccination against mumps reaches a good level of coverage only after two doses of vaccine persisting at high levels over 15 years and induces a more significant response in females.
Insights
Mumps vaccination significantly increases antibody positivity, especially with two doses. Two-dose mumps vaccination ensures high antibody levels for over 15 years, with females showing a stronger response.
Area of Science:
- * Immunology
- * Vaccinology
- * Epidemiology
Background:
- * Mumps is a global vaccine-preventable disease where vaccination has reduced transmission.
- * Understanding mumps antibody prevalence is crucial for assessing vaccine effectiveness.
Purpose of the Study:
- * To evaluate mumps antibody seropositivity in medical students based on vaccination history.
- * To analyze the impact of vaccine dose, birth year, and sex on antibody response.
Main Methods:
- * A cross-sectional study involving 11,327 medical students.
- * Assessment of mumps antibody prevalence correlated with vaccination status (dose/doses), birth year, and sex.
Main Results:
- * Two-dose mumps vaccination (85.4%) resulted in significantly higher antibody positivity than one dose (71.2%).
- * Students born after 1995, predominantly with two doses, showed near 90% seropositivity.
- * Females exhibited a significantly higher antibody response than males after both one and two doses.
- * High seropositivity (86.1%) was maintained over 15 years post-second dose.
Conclusions:
- * Two doses of the mumps vaccine are essential for achieving good coverage and sustained high antibody levels.
- * The mumps vaccine elicits a more robust immune response in females.
- * Vaccination strategies should emphasize two-dose compliance for long-term protection.
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