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Viral Structure

Viral Structure

Viruses are extraordinarily diverse in shape and size, but they all have several structural features in common. All viruses have a core that contains a DNA- or RNA-based genome. The core is surrounded by a protective coat of proteins called the capsid. The capsid is composed of subunits called capsomeres. The capsid and genome-containing core are together known as the nucleocapsid.

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Engineering Antiviral Agents via Surface Plasmon Resonance

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Targeting Viral Surface Proteins through Structure-Based Design.

Yogesh B Narkhede¹, Karen J Gonzalez², Eva-Maria Strauch^1,2

¹Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, GA 30602, USA.

|August 10, 2021

Summary

This summary is machine-generated.

Novel viral threats require new defenses. This review highlights computational design of antivirals and vaccines targeting viral fusion proteins to combat respiratory viruses.

Keywords:

computational protein design glycoproteins rational design respiratory viruses structural vaccinology vaccine

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Area of Science:

Virology
Drug Discovery
Immunology

Background:

Emerging viral infections and mutations pose significant public health risks.
Viral surface glycoproteins are critical for host cell entry and are key targets for therapeutic intervention.
Developing effective antivirals and vaccines is crucial for pandemic preparedness.

Purpose of the Study:

To review recent advancements in computational structure-based design.
To focus on targeting viral fusion machinery for antiviral and vaccine development.
To address the control of seasonal and emerging respiratory viruses.

Main Methods:

Computational structure-based drug design.
Analysis of viral fusion mechanisms.
Review of recent literature on antiviral and vaccine development targeting fusion proteins.

Main Results:

Identified surface glycoproteins as crucial targets for antiviral and vaccine strategies.
Highlighted the potential of computational approaches in designing novel therapeutics.
Summarized progress in developing interventions against respiratory viruses.

Conclusions:

Computational structure-based design offers a promising avenue for developing antivirals and vaccines.
Targeting viral fusion machinery is a viable strategy to combat respiratory viral infections.
Continued research is essential to address the threat of emerging and seasonal respiratory viruses.