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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Cell-mediated Immune Responses01:40

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Related Experiment Video

Updated: Oct 25, 2025

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Cellular based immunotherapy for primary liver cancer.

Yuanyuan Zheng1,2, Yan Li2, Jiao Feng2

  • 1Department of Gastroenterology, Putuo People's Hospital, Tongji University, Shanghai, 200060, China.

Journal of Experimental & Clinical Cancer Research : CR
|August 10, 2021
PubMed
Summary

Cellular immunotherapies offer promising new strategies for primary liver cancer (PLC) treatment, addressing challenges like recurrence and poor prognosis. This review explores lymphoid and myeloid cell-based approaches for improved PLC patient outcomes.

Keywords:
Cellular based immunotherapyCombined immunotherapyLymphoid cellMyeloid cellPrimary liver cancer

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Area of Science:

  • Oncology
  • Immunology
  • Cancer Therapy

Background:

  • Primary liver cancer (PLC) presents significant morbidity and mortality.
  • Recurrence and poor prognosis necessitate novel therapeutic strategies beyond conventional treatments.

Purpose of the Study:

  • To review cellular-based immunotherapies for primary liver cancer (PLC).
  • To explore the role of immune cells in regulating the tumor microenvironment for PLC treatment.

Main Methods:

  • Review of active and passive cellular immunotherapies for PLC.
  • Inclusion of lymphoid and myeloid cell-based therapeutic strategies.
  • Brief overview of combined immunotherapeutic approaches and challenges.

Main Results:

  • Cellular immunotherapy demonstrates inherent advantages for PLC therapy.
  • Immune cells are critical in recognizing tumor cells and modulating the tumor microenvironment.
  • Various cellular immunotherapeutic strategies, including lymphoid and myeloid cells, are discussed.

Conclusions:

  • Cellular immunotherapy represents a promising novel therapeutic avenue for primary liver cancer.
  • Optimizing current treatments and exploring innovative strategies like immunotherapy are crucial for improving PLC patient outcomes.