Unmasking antibiotic-associated neurological disorders: The underminer in Intensive Care Unit

Area of Science:

• Neurology
• Pharmacology
• Infectious Diseases

Background:

• Psychosis is a common and intractable disorder during hospitalization, particularly in Intensive Care Units (ICUs).
• The increasing use of antibiotics for community- and hospital-acquired infections has led to a rise in antibiotic-associated neurological disorders.
• Antibiotic neurotoxicity is frequently overlooked or misinterpreted, hindering timely diagnosis and treatment.

Purpose of the Study:

• To review neurological disorders associated with antibacterial agent usage.
• To systematically elucidate the pathogenesis of antibiotic-associated neurotoxic reactions.
• To emphasize the importance of early diagnosis and management of these neurotoxicities.

Main Methods:

• Systematic review of literature on neurological disorders caused by antibiotics.
• Formulation of the pathogenesis of antibiotic-associated neurotoxic reactions.
• Discussion of diagnostic and monitoring strategies.

Main Results:

• Antibiotic use can precipitate a range of neurological disorders.
• The pathogenesis of these neurotoxic reactions involves multiple mechanisms.
• Early detection and intervention are critical for preventing severe clinical outcomes.

Conclusions:

• Antibiotic-associated neurotoxicity is an underrecognized but significant clinical issue.
• Regular neurological examinations, EEG, lumbar puncture, and therapeutic drug monitoring are essential for early diagnosis.
• Prompt management of the underlying cause can lead to favorable clinical outcomes.