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Updated: Oct 25, 2025

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
11:15

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

Published on: September 20, 2016

24.6K

Molecular Alterations in Pediatric Solid Tumors

Jonathan C Slack1, Alanna J Church1

  • 1Department of Pathology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.

Surgical Pathology Clinics
|August 10, 2021
PubMed

Insights

This review summarizes key molecular alterations in pediatric solid tumors, impacting diagnosis and treatment. It highlights sequencing techniques and the growing role of molecular data in pediatric pathology.

Area of Science:

  • Pediatric oncology
  • Molecular pathology
  • Genomics

Background:

  • Pediatric tumors encompass hematologic malignancies, CNS tumors, and extracranial solid tumors.
  • Molecular alterations significantly influence diagnosis, prognosis, treatment, and hereditary cancer risk in pediatric solid tumors.
  • Understanding these alterations is crucial for advancing pediatric cancer care.

Purpose of the Study:

  • To provide a concise summary of clinically relevant molecular alterations in extracranial pediatric solid tumors.
  • To discuss conventional and next-generation sequencing techniques for molecular analysis.
  • To review tumor predisposition syndromes and the integration of molecular data in pediatric diagnostic pathology.

Main Methods:

  • Literature review of published studies on pediatric solid tumors.
  • Analysis of molecular alterations, sequencing technologies, and predisposition syndromes.
  • Synthesis of information regarding the clinical utility of molecular data in pediatric pathology.

Main Results:

  • Clinically relevant molecular alterations in extracranial pediatric solid tumors are identified.
  • Conventional and next-generation sequencing methods are detailed, emphasizing their role in molecular profiling.
  • The significance of tumor predisposition syndromes and the integration of molecular pathology in diagnosis are discussed.

Conclusions:

  • Molecular alterations are integral to understanding and managing pediatric solid tumors.
  • Advanced sequencing techniques are transforming molecular diagnostics in pediatric oncology.
  • The integration of molecular data is enhancing diagnostic accuracy and personalized treatment strategies for children with solid tumors.
Keywords:
MolecularPediatric pathologySoft tissue and bone tumorsSolid tumors

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