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L Pacoureau1, C Labeyrie2, P Catalan3

  • 1Service de médecine interne et immunologie clinique, Assistance publique-Hôpitaux Paris Saclay, Hôpital Bicêtre, 94275 Le Kremlin-Bicêtre cedex, France.

La Revue De Medecine Interne
|August 10, 2021
PubMed

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Summary
This summary is machine-generated.

Peripheral neuropathies can be linked to lymphoproliferative syndromes like multiple myeloma. Diagnosis requires collaboration and systematic electro-clinical investigation to determine the cause and mechanism of nerve damage.

Area of Science:

  • Neurology
  • Hematology
  • Oncology

Background:

  • Lymphoproliferative syndromes (LPS) encompass conditions such as multiple myeloma, Waldenström's disease, chronic lymphocytic leukemia, and lymphomas.
  • Peripheral neuropathies (PN) are a potential complication of LPS, presenting diagnostic challenges.

Purpose of the Study:

  • To outline the diagnostic approach for peripheral neuropathies associated with lymphoproliferative syndromes.
  • To emphasize the importance of interdisciplinary collaboration between internists and neurologists.

Main Methods:

  • Systematic electro-clinical investigation to determine neuropathy topography and mechanism.
  • Utilizing imaging techniques like nerve and/or plexus MRI.
  • Gathering evidence including clinical context, laboratory tests, auto-antibodies, and biopsies.
Keywords:
Anti-MAGCANOMADLymphomasLymphomesNeurolymphomatoseNeurolymphomatosisNeuropathies périphériquesPeripheral neuropathies

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Main Results:

  • The mechanisms of PN in LPS can be dysimmune, paraneoplastic, infiltrative, iatrogenic, or due to vitamin deficiency.
  • Neuropathy can be the initial presenting manifestation of an underlying LPS.
  • A comprehensive diagnostic workup is essential for accurate attribution.

Conclusions:

  • Diagnosing PN in the context of LPS requires a multifaceted approach.
  • Interdisciplinary cooperation is crucial for effective diagnosis and management.
  • Identifying the link between PN and LPS aids in timely treatment of the underlying hematologic malignancy.