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Computational estimates of daily aggregate exposure to PFOA/PFOS from 2011 to 2017 using a basic intake model.

Alexander East¹, Peter P Egeghy¹, Elaine A Cohen Hubal²

¹U.S. Environmental Protection Agency, Center for Computational Toxicology and Exposure, Research Triangle Park, NC, USA.

Journal of Exposure Science & Environmental Epidemiology

|August 10, 2021

Summary

Decreased use of per- and polyfluoroalkyl substances (PFAS) led to lower estimated daily intakes of PFOA and PFOS in adults and children. These updated exposure estimates align with observed declines in serum concentrations.

Keywords:

Aggregate daily Exposure model PFOA PFOS

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Area of Science:

Environmental Science
Toxicology
Public Health

Background:

Human exposure to per- and polyfluoroalkyl substances (PFAS) has been previously modeled to estimate serum concentrations.
Production and use of PFAS, particularly PFOA and PFOS, have decreased.
Recent concentration data from the US and other industrialized nations have become available.

Purpose of the Study:

To estimate aggregate median intakes of PFOA and PFOS using more recent data.
To update human exposure models for these persistent chemicals.

Main Methods:

Collected and averaged summary statistics from secondary sources for PFOA and PFOS in various media (air, water, dust, soil).
Mapped exposure data for adults and children.
Utilized European dietary intake estimates for food consumption.
Employed a first-order pharmacokinetic model.

Main Results:

Estimated daily intake for adults: 40 ng/day PFOA and 40 ng/day PFOS.
Estimated daily intake for children: 14 ng/day PFOA and 17 ng/day PFOS.
These estimates are substantially lower than previously reported values, reflecting decreased environmental concentrations.

Conclusions:

Updated intake estimates align with observed declines in PFOA/PFOS serum concentrations over the past decade.
The enhanced estimation approach is supported by concomitant blood concentration data.
This study provides a more accurate reflection of current human exposure levels to PFOA and PFOS.