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Small-molecule inhibitor of AF9/ENL-DOT1L/AF4/AFF4 interactions suppresses malignant gene expression and tumor growth

Fangrui Wu1,2, Shenyou Nie1, Yuan Yao1

  • 1Department of Pharmacology and Chemical Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.

Theranostics
|August 10, 2021
PubMed

Keywords:
Cancer therapeuticsMLL-rearranged leukemiaProtein-protein interactionSmall-molecule inhibitorSuper elongation complexes

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