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Related Experiment Videos

Fetal catecholamines and the Apgar score.

L Nylund1, I Dahlin, H Lagercrantz

  • 1Department of Obstetrics and Gynecology, Huddinge University Hospital, Karolinska Institute, Sweden.

Journal of Perinatal Medicine
|January 1, 1987
PubMed
Summary
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The Apgar score is not a reliable indicator of fetal acidosis in newborns. Catecholamine levels correlate negatively with pH, suggesting a link to newborn vitality rather than asphyxia.

Area of Science:

  • Neonatal Medicine
  • Biochemistry

Background:

  • The Apgar score is a standard assessment of newborn infants' condition at birth.
  • Fetal acidosis, indicated by low pH, can have significant implications for newborns.
  • Catecholamines (adrenaline and noradrenaline) are stress hormones released during birth.

Purpose of the Study:

  • To investigate the relationship between Apgar score, umbilical cord blood pH, and plasma catecholamine levels in newborns.
  • To determine if the Apgar score accurately reflects fetal acidosis or newborn vitality.

Main Methods:

  • 181 newborn infants (29-43 weeks gestation) were studied.
  • Umbilical arterial blood was collected for pH measurement.
  • Plasma adrenaline and noradrenaline were quantified using high-performance liquid chromatography.

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Main Results:

  • A significant negative correlation was observed between pH and both noradrenaline and adrenaline levels in infants with Apgar scores ≥7 and <7.
  • Infants with Apgar scores ≥7 often had pH <7.25, indicating acidosis.
  • Stronger negative correlations between catecholamines and pH were found in infants with lower Apgar scores.

Conclusions:

  • The Apgar score is an insufficient measure for diagnosing fetal acidosis.
  • Apgar scores appear to reflect the newborn's immediate vitality rather than the degree of fetal asphyxia.
  • Catecholamine levels provide a more nuanced insight into the physiological stress experienced by the newborn.