[Positive cognitive neuroscience : Positive valence systems of the Research Domain Criteria initiative]
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Updated: Oct 25, 2025

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
Published on: March 14, 2025
Henrik Walter1,2, Anna Daniels3,4, Sarah A Wellan3,4
1Klinik für Psychiatrie und Psychotherapie CCM, Forschungsbereich Mind and Brain, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, 10117, Berlin, Deutschland. henrik.walter@charite.de.
Abstract:
In this paper, the domain positive valence systems (PVS) of the Research Domain Criteria (RDoC) matrix and its subconstructs are presented and discussed. The PVS basically reflect different forms and aspects of reward processing. These have been investigated in psychiatry in the context of addiction, schizophrenia and depression for decades; the latter are therefore not the topic of this paper. This article presents the heuristic value of the RDoC system in understanding other disorders and constructs, namely the transdiagnostic symptom of anhedonia, autism spectrum disorder and eating disorders. In addition, it outlines how the PVS domain has also enriched the clinical perspective of traditional psychopathology and stimulated the development of new behavioral measurement instruments. Finally, the limitations and potential future developments of the framework are discussed.
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