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Stem Cells for Aging-Related Disorders.
Mia C Borlongan1, Jeffrey Farooq1, Nadia Sadanandan1
1Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, 33612, USA.
Stem Cell Reviews and Reports
|August 10, 2021
Summary
This review highlights stem cell therapies for aging disorders, exploring diverse stem cell sources and novel treatments for conditions like Parkinson's and Alzheimer's disease.
Area of Science:
- Regenerative Medicine
- Gerontology
- Cell Biology
Background:
- Aging is associated with a decline in tissue function and regenerative capacity.
- Stem cell therapies offer potential for treating age-related diseases.
- Understanding stem cell mechanisms is crucial for developing effective treatments.
Purpose of the Study:
- To review recent advances in stem cell research for aging-related disorders.
- To explore various stem cell sources and therapeutic strategies.
- To summarize key mechanisms involved in stem cell therapy for aging.
Main Methods:
- Review of current biological and translational research on stem cells.
- Analysis of stem cell applications in aging-related conditions (e.g., Parkinson's, Alzheimer's, vascular dementia).
- Evaluation of mechanisms of action, including long non-coding RNAs and specific receptors.
Main Results:
- Exogenous adult bone marrow-derived stem cells show promise as a safe transplantable source.
- Electrical stimulation can promote endogenous neurogenesis for Parkinson's disease.
- Small molecules and cell transplantation strategies are being investigated for Alzheimer's and vascular dementia.
Conclusions:
- Stem cell research is rapidly advancing the treatment of aging-related disorders.
- Diverse stem cell sources and therapeutic approaches are being explored.
- Further research into mechanisms of action will refine stem cell therapies for aging.
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