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Updated: Oct 25, 2025

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Published on: November 9, 2019
Cyclocarbopalladation/Stille Cascade: Stereoselective Access to Quaternary Functionalized Carbons
Océane Flores1, Patrick Wagner1, Jean Suffert1
1Laboratoire d'Innovation Thérapeutique, Université de Strasbourg, CNRS, UMR 7200, 67000 Strasbourg, France.
Abstract:
Exploration of the 4-exo-dig cyclocarbopalladation in the discovery of new and original scaffolds afforded some unexpected results. The search for a way to produce seven-membered ring systems led to polycyclic molecules bearing a tetrasubstituted carbon. The triple bond that substitutes the cyclohexene ring on the starting compound is crucial for a high stereoselectivity. This observation has been confirmed by the reaction of a nonsubstituted cyclohexene ring resulting in poor stereoselectivity and low yields.
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