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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

95
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
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Tissue Transplantation01:24

Tissue Transplantation

645
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
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Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

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Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
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Related Experiment Video

Updated: Oct 25, 2025

Heterotopic Renal Autotransplantation in a Porcine Model: A Step-by-Step Protocol
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Age disparities in transplantation.

Fabio Melandro1, Serena Del Turco2, Davide Ghinolfi1

  • 1Division of Hepatic Surgery and Liver Transplantation, University of Pisa Medical School Hospital.

Current Opinion in Organ Transplantation
|August 10, 2021
PubMed
Summary

Age disparities in organ transplantation harm both recipients and donors. Optimizing organ utilization and allocation systems can improve equity and reduce waiting list mortality for all patients needing transplants.

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Area of Science:

  • Transplantation research
  • Organ allocation systems
  • Geriatric medicine

Background:

  • Significant age-related disparities exist in accessing liver and kidney transplantation.
  • These disparities affect both potential recipients and organ donors, influencing transplant center practices.
  • The utilization of older donors impacts waiting list mortality and patient dropout rates.

Purpose of the Study:

  • To review age-related disparities in liver and kidney transplantation.
  • To identify age categories adversely affected by current practices.
  • To examine how allocation systems can mitigate these disparities.

Main Methods:

  • Literature review of age disparities in organ transplantation.
  • Analysis of donor and recipient age factors in transplant access.
  • Evaluation of organ allocation system impacts on equity.

Main Results:

  • Certain age groups face significant barriers to transplantation.
  • Donor age critically influences waiting list outcomes.
  • Current allocation systems may exacerbate or alleviate age-based disparities.

Conclusions:

  • A balanced approach is needed to address the needs of younger and older patients.
  • Maximizing organ utility from older donors can increase graft availability.
  • Revising allocation systems to balance equity and utility is crucial for improving survival benefits and reducing waiting list attrition.