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Investigating barriers to the protective efficacy provided by rotavirus vaccines in African infants

Julie E Bines1,2,3

  • 1Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia.

Plos Medicine
|August 10, 2021
PubMed

Abstract:

Julie Bines discusses an accompanying study by Sheila Isanaka and colleagues on nutrient supplementation and immune responses to rotavirus vaccination.

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The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
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