Related Experiment Video
Updated: Oct 25, 2025
A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
Coronary Stenting: Reflections on a 35-Year Journey
Bradley H Strauss1, Jean-François Tanguay2, Fabien Picard3
1Schulich Heart Program, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; University of Toronto, Toronto, Ontario, Canada.
Insights
Coronary stenting, a minimally invasive procedure, has evolved significantly over 35 years, improving outcomes for heart conditions. Despite challenges like stent thrombosis, ongoing innovations promise future advancements in cardiovascular therapy.
Area of Science:
- Cardiovascular Medicine
- Interventional Cardiology
- Medical Device Technology
Background:
- Coronary stenting has become the most common minimally invasive procedure worldwide.
- It has significantly impacted outcomes for acute myocardial infarction and acute coronary syndromes.
- The therapy has undergone extensive study through numerous randomized clinical trials.
Purpose of the Study:
- To trace the historical evolution of coronary stenting.
- To highlight key advancements and challenges in stent technology and application.
- To provide perspective on the current state and future trajectory of coronary stenting.
Main Methods:
- Review of historical data and clinical trial evidence.
- Analysis of advancements in stent materials, design, and coatings.
- Examination of procedural innovations and their impact on patient outcomes.
Main Results:
- Coronary stenting has seen rapid growth and expansion of indications, followed by contractions based on evidence.
- Initial challenges included stent thrombosis and restenosis.
- Recent developments like bioabsorbable scaffolds have presented new considerations.
Conclusions:
- Coronary stenting is a dynamic field with continuous innovation in materials and design.
- Clinical trial evidence has shaped the indications and use of coronary stents.
- Future iterations of stent technology are expected to further advance cardiovascular treatment.
Abstract:
Stenting was introduced as a therapy for coronary artery disease 35 years ago, and is currently the most commonly performed minimally invasive procedure globally. Percutaneous coronary revascularization, initially with plain old balloon angioplasty and later with stenting, has dramatically affected the outcomes of acute myocardial infarction and acute coronary syndromes. Coronary stenting is probably the most intensively studied therapy in medicine on the basis of the number of randomized clinical trials for a broad range of indications. Continuous improvements in stent materials, design, and coatings concurrent with procedural innovations have truly been awe-inspiring. The story of stenting is replete with high points and some low points, such as the initial experience with stent thrombosis and restenosis, and the more recent disappointment with bioabsorbable scaffolds. History has shown rapid growth of stent use with expansion of indications followed by contraction of some uses in response to clinical trial evidence in support of bypass surgery or medical therapy. In this review we trace the constantly evolving story of the coronary stent from the earliest experience until the present time. Undoubtedly, future iterations of stent design and materials will continue to move the stent story forward.
Related Concept Videos
01:27Coronary Artery Disease V: Interprofessional Care
01:24Cardiac Catheterization III: Left Heart Catheterization
01:22Mitral Stenosis I: Introduction
01:30Coronary Artery Disease I: Introduction
01:30Acute Coronary Syndrome I: Introduction
01:21Cardiac Catheterization II: Right Heart Catheterization