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Updated: Oct 25, 2025
Engineering Molecular Recognition with Bio-mimetic Polymers on Single Walled Carbon Nanotubes
Published on: January 10, 2017
Fast screening test for molecular recognition of levodopa and dopamine in biological samples using 3D printed
Catalina Cioates Negut1, Sorin Sebastian Gheorghe2, Raluca-Ioana Stefan-van Staden3
1Laboratory of Electrochemistry and PATLAB, National Institute of Research for Electrochemistry and Condensed Matter, 202 Splaiul Independentei Str., 060021, Bucharest-6, Romania.
Abstract:
The simultaneous assay of levodopa and dopamine is essential for diagnosis and treatment of neurodegenerative diseases and brain cancer. 3D stochastic microsensors based on multi-walled carbon nanotubes (MWCNTs), gold nanoparticles (AuNPs) and 1-adamantyloleamide (AOA) was used for the simultaneous molecular recognition of levodopa and dopamine in biological samples (whole blood, urine, and brain tissue). The proposed 3D stochastic microsensors presented low limits of quantification, and high sensitivities. High selectivity was recorded versus neurotransmitters such as epinephrine, norepinephrine, serotonin, and glutamate. High recoveries were obtained for the assay of both levodopa and dopamine in whole blood, urine, and tumor tissue samples.
