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Essential Minerals for Bone Health

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Updated: Oct 25, 2025

Rapid Mix Preparation of Bioinspired Nanoscale Hydroxyapatite for Biomedical Applications

Rapid Mix Preparation of Bioinspired Nanoscale Hydroxyapatite for Biomedical Applications

Published on: February 23, 2017

Silver, silicon co-substituted hydroxyapatite modulates bacteria-cell competition for enhanced osteogenic function.

Poon Nian Lim¹, Zuyong Wang², Shi Yun Tong¹

¹Department of Mechanical Engineering, National University of Singapore, Singapore, Singapore.

Biomedical Materials (Bristol, England)

|August 10, 2021

Summary

This study introduces Ag,Si-HA, a novel biomaterial for orthopedics. It effectively combats bacterial infections and promotes bone tissue regeneration, addressing pre-operative contamination challenges.

Keywords:

apatite bacteria contamination model pre-operative infection stem cells

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Area of Science:

Biomaterials Science
Orthopedic Surgery
Regenerative Medicine

Background:

Orthopedic biomaterials face challenges with pre-operative contamination, necessitating strategies to combat bacteria while promoting tissue healing.
Developing materials that can manage infection and support bone regeneration is crucial for successful orthopedic interventions.

Purpose of the Study:

To evaluate the efficacy of a modified hydroxyapatite, Ag,Si-HA, in combating bacterial infections and promoting bone marrow-derived mesenchymal stem cells (BMSCs) osteogenic differentiation.
To assess the biomaterial's performance in simulated surgical site and infected implant environments.

Main Methods:

Functional modification of hydroxyapatite to create Ag,Si-HA.
Co-culture of Ag,Si-HA with human BMSCs and *Pseudomonas aeruginosa* in simulated infection models.
Assessment of bacterial adhesion, suppression, killing, cytotoxicity, and BMSCs osteogenic differentiation over 28 days.

Main Results:

Ag,Si-HA demonstrated preferential adhesion of BMSCs over *P. aeruginosa*.
The material exhibited immediate bacterial suppression and killing with minimal cytotoxicity for 28 days.
Ag,Si-HA stimulated BMSCs osteogenic differentiation even in a contaminated environment.

Conclusions:

Ag,Si-HA possesses dual functionality, acting as an effective antibacterial agent and promoting bone tissue regeneration.
These findings establish requirements for antibacterial biomaterials in managing pre-operative contamination in orthopedics.
The study highlights Ag,Si-HA's potential for orthopedic applications involving infection and bone repair.