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Urinary Kringle Domain-Containing Protein HGFL: A Validated Biomarker of Early Sickle Cell Anemia-Associated Kidney

Sergei Nekhai1,2,3, Xionghao Lin2,4, Simran Soni3

  • 1Department of Microbiology, College of Medicine, Howard University, Washington, District of Columbia, USA.

American Journal of Nephrology
|August 10, 2021
PubMed

Insights

Novel urinary HGFL biomarkers can help detect early chronic kidney disease (CKD) in sickle cell anemia (SCA) patients. HGFL aids in predicting CKD progression more effectively than traditional eGFR measurements.

Area of Science:

  • Nephrology
  • Hematology
  • Biomarker Discovery

Background:

  • Chronic kidney disease (CKD) is a common complication in sickle cell anemia (SCA).
  • Hyperfiltration often masks early CKD detection in SCA patients.
  • Novel urinary biomarkers are needed to predict renal disease progression.

Purpose of the Study:

  • To identify novel urinary biomarkers for early CKD detection in SCA.
  • To assess the utility of identified biomarkers in predicting CKD progression.

Main Methods:

  • Mass spectrometry analysis of urinary samples.
  • Identification of kringle domain-containing protein HGFL.
  • Correlation analysis of HGFL levels with CKD stages and eGFR.

Main Results:

  • Urinary HGFL levels correlated with hyperfiltration and were reduced in early CKD stages.
  • HGFL levels negatively correlated with CKD progression.
  • HGFL-based prediction of CKD progression to stage 2 outperformed eGFR.
  • Validation in an independent patient cohort confirmed HGFL's utility.

Conclusions:

  • Urinary HGFL shows potential as a biomarker for early CKD diagnosis in SCA patients.
  • HGFL provides additional diagnostic information beyond eGFR.
  • HGFL may improve the management of renal complications in SCA.
Abstract

Keywords:
Chronic kidney diseaseGlomerular filtration rateHGFLHyperfiltrationSelected reaction monitoringSickle cell anemia

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