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Cross-sectional study of aortic valve calcification and cardiovascular risk factors in older Danish men

Lida Khurrami1, Jacob Eifer Møller2,3, Jes Sanddal Lindholt4,5,6

  • 1Department of Cardiology, Odense University Hospital, Odense, Denmark drlkdk@gmail.com.

Heart (British Cardiac Society)
|August 11, 2021
PubMed

Insights

Aortic valve calcification is common in older men and linked to cardiovascular risk factors. Its association with risk factors is selective after accounting for coronary artery calcification.

Area of Science:

  • Cardiology
  • Radiology
  • Preventive Medicine

Background:

  • Aortic valve calcification (AVC) and coronary artery calcification (CAC) are key indicators of cardiovascular disease (CVD).
  • These calcifications are presumed to share common risk factors.
  • Understanding AVC prevalence and its associations is crucial for CVD risk assessment.

Purpose of the Study:

  • To determine the prevalence and extent of AVC in men aged 60-74 years.
  • To assess the association between AVC and cardiovascular risk factors, including CAC and biomarkers.
  • To explore shared risk factors between AVC and CAC.

Main Methods:

  • Utilized data from the DANish CArdioVAscular Screening and intervention trial (DANCAVAS).
  • Included 14,073 men aged 60-74 years without prior valve replacement.
  • Calcification scores (AVC and CAC) were measured using non-contrast CT scans; risk factor associations were analyzed via regression.

Main Results:

  • AVC was prevalent, with 58.0% having a score >0.
  • Age, hypertension, obesity, known CVD, and serum phosphate remained significantly associated with AVC after adjusting for CAC ≥400.
  • Smoking, diabetes, hyperlipidemia, eGFR, and serum calcium were not significantly associated with AVC after adjustment for CAC.

Conclusions:

  • AVC is prevalent in the general population of men aged 60-74.
  • AVC is significantly associated with cardiovascular risk factors.
  • These associations are selective after adjustment for coronary artery calcification (CAC).
Abstract

Keywords:
coronary angiographycoronary artery diseasediagnostic imagingheart valve diseasesrisk factors

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