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Related Experiment Video

Updated: Oct 25, 2025

Uniportal Full Endoscopic Posterolateral Transforaminal Lumbar Interbody Fusion
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Allografts and Spinal Fusion.

Justin D Cohen1, Linda E Kanim2,3, Andrew J Tronits2,3

  • 1Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, California.

International Journal of Spine Surgery
|August 11, 2021
PubMed
Summary

Bone allografts are crucial for spinal fusion success, providing structural support and aiding bone regeneration. This review examines current allograft products and their efficacy in clinical and animal studies.

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Area of Science:

  • Orthopedic Surgery
  • Biomaterials Science
  • Regenerative Medicine

Background:

  • Back pain is a prevalent condition in the US with diverse causes.
  • Spinal fusion surgery is a common treatment, relying on instrumentation, construct design, and bone grafts.
  • Bone allografts are vital for structural integrity and bone fusion in spinal procedures.

Purpose of the Study:

  • To review bone allografts used in spinal fusion.
  • To focus on currently available allograft products.
  • To emphasize recent product development and applications in spinal fusion.

Main Methods:

  • Literature searches were conducted using keywords like "allografts" and "bone."
  • Searches included major databases such as PubMed, Google Scholar, FDA-510k approvals, and clinicaltrials.gov.
Keywords:
allograftbone graft materialbone graftsspine fusion

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Computed Tomography and Optical Imaging of Osteogenesis-angiogenesis Coupling to Assess Integration of Cranial Bone Autografts and Allografts
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  • The review encompasses both animal and clinical studies.

    • Main Results:

    • The study reviews available bone allograft products.
    • It assesses the success of these allografts in animal models.
    • Clinical study outcomes regarding allograft efficacy are also examined.

    Conclusions:

    • Bone grafts are categorized into autogenous, allograft, and synthetic types.
    • This paper concentrates on allografts, detailing subtypes and their applications.
    • Recent advancements in allograft products for spinal fusion are highlighted.