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Updated: Oct 25, 2025

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Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus
Published on: March 8, 2015
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[Surgical Technique of Ventral Intermediate Thalamic Deep Brain Stimulation]
Takashi Morishita1, Hideaki Tanaka, Tooru Inoue
1Department of Neurosurgery, Fukuoka University Faculty of Medicine.
No Shinkei Geka. Neurological Surgery
|August 11, 2021
Summary
Deep brain stimulation (DBS) of the ventral intermediate (Vim) nucleus effectively treats tremors. This review details the basic concept and surgical approach for Vim DBS, highlighting technical variations in electrode trajectory planning.
Area of Science:
- Neurosurgery
- Neurology
- Medical Engineering
Background:
- Deep brain stimulation (DBS) targeting the ventral intermediate (Vim) nucleus is a recognized treatment for tremor disorders.
- Significant technical variations exist among specialists performing Vim DBS.
- Essential tremor (ET) and tremor-dominant Parkinson's disease (PD) are primary indications, with other tremors like Holmes tremor also treated.
Purpose of the Study:
- To elucidate the fundamental principles of Vim DBS.
- To present a specific surgical methodology for Vim DBS.
- To address the technical variations in preoperative imaging and electrode trajectory planning.
Main Methods:
- Review of the basic concept of Vim DBS.
- Detailed explanation of a specific surgical method for Vim DBS.
- Discussion of preoperative imaging and planning techniques for electrode placement.
Main Results:
- Established understanding of Vim DBS principles.
- Presentation of a defined surgical technique.
- Identification of key areas of technical variation in surgical planning.
Conclusions:
- Vim DBS is a valuable therapeutic option for various tremor conditions.
- Standardization of surgical techniques, particularly in planning, may improve outcomes.
- Further research into optimizing DBS electrode placement is warranted.

