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Differences in actin expression between primary and recurrent facial basal cell carcinomas as a prognostic factor of
Katarzyna Iwulska1, Grażyna Wyszyńska-Pawelec1, Jan Zapała1
1Department of Cranio-Maxillofacial, Oncological and Reconstructive Surgery, Jagiellonian University Medical College, Krakow, Poland.
Introduction:
Due to a relatively high recurrence rate of facial basal cell carcinoma (BCC), its morbidity is very significant.
Aim:
To analyse the expression of α-SMA, E-cadherin, Ber-Ep4 and MOC-31 as predictors of local recurrence in a group of patients with primary and recurrent BCCs of the face in correlation with histological and clinical data.
Material And Methods:
The study cohort included 79 patients with facial BCC (52 with primary BCC and 27 with recurrent BCC) who were treated at the Department of Cranio-Maxillofacial Surgery of the Jagiellonian University, Krakow in 1997-2009.
Results:
Significant risk factors for local recurrence included: recurrent tumour (p = 0.001), multifocal BCC (p = 0.01), incomplete tumour excision (p = 0.02) and the aggressive infiltrating histologic subtype of BCC (p = 0.05). In the group of primary BCCs, positive expression of stromal α-SMA (p = 0.03) correlated with a statistically significant higher recurrence rate and so did positive expression of α-SMA in tumour cells of recurrent BCC (p = 0.002). In the group of primary aggressive BCC subtypes, reduced expression of MOC-31 was also associated with a higher rate of relapse (p = 0.02).
Conclusions:
Our findings provide information about α-SMA and MOC-31 expression in primary and recurrent BCCs. These data may contribute to the formulation of a more targeted treatment plan and follow-up strategy for patients with facial basal cell carcinoma.
