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Correlation between serum 25-hydroxyvitamin D level and coronary heart disease
Insights
Low vitamin D and high interleukin-6 levels are linked to coronary heart disease (CHD) severity. This study highlights their association with disease progression in patients with CHD.
Area of Science:
- Cardiology
- Biochemistry
- Immunology
Background:
- Coronary heart disease (CHD) remains a leading cause of mortality worldwide.
- Interleukin-6 (IL-6) is a pro-inflammatory cytokine implicated in cardiovascular disease.
- Vitamin D deficiency is increasingly recognized as a potential risk factor for various chronic conditions, including cardiovascular diseases.
Purpose of the Study:
- To investigate the correlation between serum 25-hydroxyvitamin D [25(OH)D] levels, interleukin-6 (IL-6) concentrations, and the severity of coronary heart disease (CHD).
Main Methods:
- 150 patients with suspected myocardial ischemia were analyzed.
- Patients were categorized into normal (n=40) and CHD (n=110) groups based on coronary angiography.
- CHD patients were further stratified by Gensini score (low, moderate, high risk) to assess disease severity.
Main Results:
- Serum 25(OH)D levels were significantly lower, while IL-6 levels and Essen Stroke Risk Scale (ESRS) scores were significantly higher in the CHD group compared to the normal group.
- In the CHD group, increasing coronary artery stenosis severity correlated with higher Gensini scores, elevated IL-6, and higher ESRS scores, but decreased 25(OH)D levels.
- Pearson correlation confirmed a positive association between IL-6 and CHD severity (r=0.724, P < 0.001) and a negative association between 25(OH)D and CHD severity (r=-0.522, P < 0.001).
Conclusions:
- Reduced serum 25(OH)D and elevated IL-6 levels are significantly associated with the severity of coronary heart disease.
- These findings may offer valuable insights for the clinical diagnosis, treatment strategies, and prognosis assessment of CHD patients.
Objective:
To test the relationship between serum 25-hydroxyvitamin D[25(OH)D], interleukin-6 (IL-6), and the severity of coronary heart disease (CHD).
Methods:
A total of 150 patients with suspected myocardial ischemia presenting to our hospital from January 2018 to January 2020 were recruited. All patients underwent percutaneous coronary angiography (CAG). According to CAG results, they were divided into normal group (n=40) and CHD group (n=110). According to the coronary Gensini score, CHD patients were divided into 62 cases in the low-risk group (< 20 points), 31 cases in the moderate-risk group (20-40 points), and 17 cases in the high-risk group (> 40 points). The Gensini scores and serum 25(OH)D and IL-6 levels in each group were recorded, and the correlation between the serum 25(OH)D and IL-6 levels and the severity of the disease was analyzed. The Essen Stroke Risk Scale (ESRS) was evaluated and compared between the two groups.
Results:
The serum 25(OH)D, IL-6 level, and ESRS score in the CHD group and the normal group statistically differed (P < 0.05). In the CHD group, Gensini score, serum IL-6 level and ESRS score increased with the increase of coronary artery stenosis, and 25(OH)D level decreased with the increase of coronary artery stenosis, and all the differences were significant (P < 0.05). Pearson correlation analysis demonstrated that serum IL-6 levels in patients with CHD are positively correlated with the severity of the disease (r=0.724, P < 0.001), and 25(OH)D levels are in a negative relation (r=-0.522, P < 0.001).
Conclusion:
A decrease of serum 25(OH)D level and increase in IL-6 level in patients with CHD are associated with the severity of CHD. This may provide a reference for clinical diagnosis, treatment, and prognosis.
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