Correlation between serum 25-hydroxyvitamin D level and coronary heart disease

Area of Science:

• Cardiology
• Biochemistry
• Immunology

Background:

• Coronary heart disease (CHD) remains a leading cause of mortality worldwide.
• Interleukin-6 (IL-6) is a pro-inflammatory cytokine implicated in cardiovascular disease.
• Vitamin D deficiency is increasingly recognized as a potential risk factor for various chronic conditions, including cardiovascular diseases.

Purpose of the Study:

• To investigate the correlation between serum 25-hydroxyvitamin D [25(OH)D] levels, interleukin-6 (IL-6) concentrations, and the severity of coronary heart disease (CHD).

Main Methods:

• 150 patients with suspected myocardial ischemia were analyzed.
• Patients were categorized into normal (n=40) and CHD (n=110) groups based on coronary angiography.
• CHD patients were further stratified by Gensini score (low, moderate, high risk) to assess disease severity.

Main Results:

• Serum 25(OH)D levels were significantly lower, while IL-6 levels and Essen Stroke Risk Scale (ESRS) scores were significantly higher in the CHD group compared to the normal group.
• In the CHD group, increasing coronary artery stenosis severity correlated with higher Gensini scores, elevated IL-6, and higher ESRS scores, but decreased 25(OH)D levels.
• Pearson correlation confirmed a positive association between IL-6 and CHD severity (r=0.724, P < 0.001) and a negative association between 25(OH)D and CHD severity (r=-0.522, P < 0.001).

Conclusions:

• Reduced serum 25(OH)D and elevated IL-6 levels are significantly associated with the severity of coronary heart disease.
• These findings may offer valuable insights for the clinical diagnosis, treatment strategies, and prognosis assessment of CHD patients.