Electrooxidative dearomatization of biaryls: synthesis of tri- and difluoromethylated spiro[5.5]trienones
Yan Zhang1, Chanchan Ma1, Julia Struwe2
1Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, Zhejiang Normal University China zhangyan001@zjnu.edu.cn.
Abstract:
Radical spirocyclization via dearomatization has emerged as an attractive strategy for the rapid synthesis of structurally diverse spiro molecules. We report the use of electrochemistry to perform an oxidative dearomatization of biaryls leading to tri- and difluoromethylated spiro[5.5]trienones in a user friendly undivided cell set-up and a constant current mode. The catalyst- and chemical oxidant-free dearomatization procedure features ample scope, and employs electricity as the green and sole oxidant.
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