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The Role of the MCTS1 and DENR Proteins in Regulating the Mechanisms Associated with Malignant Cell Transformation

E Y Shyrokova1,2, V S Prassolov1, P V Spirin1

  • 1Engelhardt Institute of Molecular Biology, Russian Academy of Science, Moscow, 119991 Russia.

Acta Naturae
|August 11, 2021
PubMed

Insights

Malignant cell transformation disrupts gene expression, affecting cell signaling pathways crucial for growth and survival. Identifying key proteins like MCTS1 and DENR is vital for advancing anti-cancer biomedicine and developing targeted therapies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biomedicine

Background:

  • Malignant cell transformation involves disruptions in normal gene expression.
  • Key proteins regulate critical signaling pathways controlling cell differentiation, proliferation, and apoptosis.
  • Imbalances in these pathways can lead to tumor formation.

Purpose of the Study:

  • To highlight the significance of detecting target genes and proteins in malignant transformation.
  • To underscore the role of MCTS1 and DENR proteins in oncogenesis.

Main Methods:

  • Analysis of gene expression changes during malignant transformation.
  • Identification of proteins involved in disrupted signaling pathways.
  • Review of current data on MCTS1 and DENR functions in cancer.

Main Results:

  • Mutations disrupt expression of numerous normal genes.
  • Altered signaling pathways contribute to uncontrolled cell growth and tumor development.
  • Emerging data implicates MCTS1 and DENR in the process of oncogenesis.

Conclusions:

  • Detecting specific genes and proteins is a major advancement in anti-cancer strategies.
  • MCTS1 and DENR are significant players in oncogenesis, offering potential therapeutic targets.
Keywords:
MCTS1 and DENR proteinsapoptosiscell cyclemalignant cell transformationsignaling pathwaystranslation initiation factors

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