Related Experiment Video
Updated: Oct 25, 2025

A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation
Published on: April 2, 2012
Kluver-Bucy Syndrome: A Rare Complication of Herpes Simplex Encephalitis
Raquel Costa1, Joana Fontes1, Tiago Mendes1
1Unidade Local Saúde Alto Minho, Hospital Conde de Bertiandos, Ponte de Lima, Portugal.
Abstract:
Kluver-Bucy syndrome (KBS) is a characterized by a group of cognitive dysfunctions that include hypersexuality, placidity, hyperorality, memory deficits and hypermetamorphosis. This syndrome is often seen in pathological states that destroy the temporal lobes, normally bilaterally. Herpes simplex encephalitis (HSE) is one of the causes of KBS, as the herpes virus can cause dysfunction/destruction of the temporal lobes. KBS is a very rare syndrome, with just a few cases described in the literature. We present the case of a 21-year-old-man who was diagnosis with KBS after HSE.
Learning Points:
Kluver-Bucy syndrome (KBS) should be kept in mind in patients with visual agnosia, hypermetamorphosis, memory disturbances, hypersexuality and placidity.Neurological causes of KBS should be treated quickly.Treatment of KBS is still very challenging.

